产品
编 号：F760777
分子式：C22H30N2O
分子量：338.49
分子式：C22H30N2O
分子量：338.49
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CAS No: 857262-16-9
产品详情
生物活性：
SR-16435 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor Ki=7.49; μ-Opioid receptor Ki=2.70). SR-16435 can relieve pain.
体内研究：
SR 16435 (10, 30 mg/kg; s.c.; single-dose) produces dose-dependent increase in tail-flick latency and induces antinociception.SR 16435 (10, 30 mg/kg; s.c. once daily for 9 days) produces an increase in tail-lick latency across days, induces conditioned place preference, and decreases global activity.Animal Model:20 to 25 g male ICR mice
Dosage:10, 30 mg/kg
Administration:s.c. for single-dose
Result:Produced dose-dependent increase in tail-flick latency and induced antinociception.
Animal Model:20 to 25 g male ICR mice
Dosage:10, 30 mg/kg
Administration:s.c. once daily for 9 days
Result:Produced an increase in tail-lick latency across days, induced conditioned place preference, and decreased global activity.
SR-16435 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor Ki=7.49; μ-Opioid receptor Ki=2.70). SR-16435 can relieve pain.
体内研究：
SR 16435 (10, 30 mg/kg; s.c.; single-dose) produces dose-dependent increase in tail-flick latency and induces antinociception.SR 16435 (10, 30 mg/kg; s.c. once daily for 9 days) produces an increase in tail-lick latency across days, induces conditioned place preference, and decreases global activity.Animal Model:20 to 25 g male ICR mice
Dosage:10, 30 mg/kg
Administration:s.c. for single-dose
Result:Produced dose-dependent increase in tail-flick latency and induced antinociception.
Animal Model:20 to 25 g male ICR mice
Dosage:10, 30 mg/kg
Administration:s.c. once daily for 9 days
Result:Produced an increase in tail-lick latency across days, induced conditioned place preference, and decreased global activity.
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