产品
编 号：F083867
分子式：C34H29ClN6O3
分子量：605.09
分子式：C34H29ClN6O3
分子量：605.09
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 122956-68-7
产品详情
生物活性：
(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection.
体内研究：
(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection.(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC50=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively).(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia.Animal Model:8- to 10-week-old BALB/c mice (DEN-2 strain infected)
Dosage:10 mg/kg
Administration:P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10
Result:Decreased by approximately 50% the lethality associated with DEN-2 infection.
Animal Model:Male BALB/C (8- to 10- week-old) wild-type mice
Dosage:5, 10 and 20 mg/kg
Administration:P.o.
Result:Dose-dependently inhibited the Zymosan -induced articular hyperalgesia.
(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection.
体内研究：
(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection.(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC50=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively).(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia.Animal Model:8- to 10-week-old BALB/c mice (DEN-2 strain infected)
Dosage:10 mg/kg
Administration:P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10
Result:Decreased by approximately 50% the lethality associated with DEN-2 infection.
Animal Model:Male BALB/C (8- to 10- week-old) wild-type mice
Dosage:5, 10 and 20 mg/kg
Administration:P.o.
Result:Dose-dependently inhibited the Zymosan -induced articular hyperalgesia.
产品资料
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