产品
编 号：F083985
分子式：C17H17NO2
分子量：267.32
分子式：C17H17NO2
分子量：267.32
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CAS No: 123039-93-0
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生物活性：
Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity. Dihydrexidine can stimulate YAP phosphorylation.
体内研究：
Dihydrexidine has poor oral bioavailability and a relatively short half-life of 1 to 2 h.Dihydrexidine (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo.Animal Model:Adult male Sprague–Dawley rats (275-300 g)
Dosage:Adult male Sprague–Dawley rats (275-300 g)
Administration:Intraperitoneal injection
Result:Produces prominent dopamine D1 receptor agonist effects in vivo
体外研究：
Dihydrexidine (DAR-0100) strongly increased YAP phosphorylation in U2OS cells.
Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity. Dihydrexidine can stimulate YAP phosphorylation.
体内研究：
Dihydrexidine has poor oral bioavailability and a relatively short half-life of 1 to 2 h.Dihydrexidine (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo.Animal Model:Adult male Sprague–Dawley rats (275-300 g)
Dosage:Adult male Sprague–Dawley rats (275-300 g)
Administration:Intraperitoneal injection
Result:Produces prominent dopamine D1 receptor agonist effects in vivo
体外研究：
Dihydrexidine (DAR-0100) strongly increased YAP phosphorylation in U2OS cells.
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