产品
编 号：F084589
分子式：C28H28ClFN2O3
分子量：494.98
分子式：C28H28ClFN2O3
分子量：494.98
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CAS No: 1233332-37-0
产品详情
生物活性：
Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach.
体内研究：
Ex26 (i.p.; 3 mg/kg; once daily; 3 d) treatment disrupts S1P1 signaling inhibiting the lymphocyte and thymocyte egress.Ex26 (i.p.; 30 mg/kg; once daily; 15 d) treatment alleviates experimental autoimmune encephalomyelitis by S1P1 antagonism.Animal Model:Eight-week-old male C57Bl/6J mice
Dosage:3 mg/kg
Administration:Intraperitoneal injection; 3 mg/kg; once daily; 3 days
Result:Induced lymphocyte sequestration at low doses, possessing an ED50 of 0.06 mg/kg after 2 hours treatment. Led to significant retention of T and B cells within the lymph nodes and significant decreases in T and B cells within the spleen.
Animal Model:Eight-week-old male C57Bl/6J mice induced with experimental autoimmune encephalomyelitis
Dosage:30 mg/kg
Administration:Intraperitoneal injection; 30 mg/kg; once daily; 15 days
Result:Inhibited both lymphocyte infiltration and destruction of the white matter in the spinal cord of mice euthanized at the end of the experiment.
体外研究：
Ex26 (0-10 μM; 1 h) treatment shows excellent selectivity for S1P1 over other Sphingosine 1-phosphate receptors.
Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach.
体内研究：
Ex26 (i.p.; 3 mg/kg; once daily; 3 d) treatment disrupts S1P1 signaling inhibiting the lymphocyte and thymocyte egress.Ex26 (i.p.; 30 mg/kg; once daily; 15 d) treatment alleviates experimental autoimmune encephalomyelitis by S1P1 antagonism.Animal Model:Eight-week-old male C57Bl/6J mice
Dosage:3 mg/kg
Administration:Intraperitoneal injection; 3 mg/kg; once daily; 3 days
Result:Induced lymphocyte sequestration at low doses, possessing an ED50 of 0.06 mg/kg after 2 hours treatment. Led to significant retention of T and B cells within the lymph nodes and significant decreases in T and B cells within the spleen.
Animal Model:Eight-week-old male C57Bl/6J mice induced with experimental autoimmune encephalomyelitis
Dosage:30 mg/kg
Administration:Intraperitoneal injection; 30 mg/kg; once daily; 15 days
Result:Inhibited both lymphocyte infiltration and destruction of the white matter in the spinal cord of mice euthanized at the end of the experiment.
体外研究：
Ex26 (0-10 μM; 1 h) treatment shows excellent selectivity for S1P1 over other Sphingosine 1-phosphate receptors.
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