产品
编 号：F084771
分子式：C28H25NO6
分子量：471.5
分子式：C28H25NO6
分子量：471.5
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
1494
In-stock
1mg
400
In-stock
5mg
1440
In-stock
10mg
2080
In-stock
25mg
3520
In-stock
50mg
4960
In-stock
100mg
6800
In-stock
结构图
CAS No: 1233706-88-1
产品详情
生物活性：
CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.
体内研究：
CAY10650 (50 μg/5 μL; Inject with topical eye-drop; Chinese hamsters) relieves acanthamoeba keratitis in vivo..Animal Model:Chinese hamsters with infected with parasite-laden contact lenses
Dosage:50 μg/5 μL
Administration:Inject with topical eye-drop under the contact lens; three times a day for 6 days and topically on days 7 to 20 postinfection
Result:Reduced the severity of the keratitis and hasten the onset of resolution.Had little mild inflammation and very few PMNs infiltration in the corneal stroma.
体外研究：
CAY10650 (12 nM; 30 min; neutrophils) inhibits the expression of the phosphorylated cPLA2-α (p-cPLA2-α) in cells.CAY10650 (12 nM; 2 h; neutrophils) inhibits PGE2 release in neutrophils.
CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.
体内研究：
CAY10650 (50 μg/5 μL; Inject with topical eye-drop; Chinese hamsters) relieves acanthamoeba keratitis in vivo..Animal Model:Chinese hamsters with infected with parasite-laden contact lenses
Dosage:50 μg/5 μL
Administration:Inject with topical eye-drop under the contact lens; three times a day for 6 days and topically on days 7 to 20 postinfection
Result:Reduced the severity of the keratitis and hasten the onset of resolution.Had little mild inflammation and very few PMNs infiltration in the corneal stroma.
体外研究：
CAY10650 (12 nM; 30 min; neutrophils) inhibits the expression of the phosphorylated cPLA2-α (p-cPLA2-α) in cells.CAY10650 (12 nM; 2 h; neutrophils) inhibits PGE2 release in neutrophils.
产品资料
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