产品
编 号：F084837
分子式：C19H16N2O3S2
分子量：384.47
分子式：C19H16N2O3S2
分子量：384.47
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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50mg
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结构图
CAS No: 1233948-61-2
产品详情
生物活性：
EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer.
体内研究：
EL-102 (12 and 15 mg/kg; p.o. 5-day on and 2-day off, from 13 to 37 days after tumour transplantation) potentiates effects of docetaxel in vivo.Animal Model:Nude mice with CWR22 xenografts
Dosage:12 and 15 mg/kg
Administration:Oral gavage; 12 and 15 mg/kg 5-day on and 2-day off; from 13 to 37 days after tumour transplantation
Result:Showed no effect on tumor growth, but enhanced the effect of docetaxel on tumor .
体外研究：
EL-102 (0-120 nM; 72 h) inhibits prostate cancer cells proliferation in vitro.EL-102 (0-100 nM; 72 h) shows cytotoxicity to prostate cancer cell lines.EL-102 (10-100 nM; 24-72 h) induces cellular apoptosis and affects cell cycle.EL-102 (10-100 nM; 24-48 h) affects PARP cleavage in DU145 cells.EL-102 (5 nM; 0-60 min) inhibits tubulin polymerisation activity.EL-102 (0-100 nM; 1 hour) inhibits Hif1α protein expression.
EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer.
体内研究：
EL-102 (12 and 15 mg/kg; p.o. 5-day on and 2-day off, from 13 to 37 days after tumour transplantation) potentiates effects of docetaxel in vivo.Animal Model:Nude mice with CWR22 xenografts
Dosage:12 and 15 mg/kg
Administration:Oral gavage; 12 and 15 mg/kg 5-day on and 2-day off; from 13 to 37 days after tumour transplantation
Result:Showed no effect on tumor growth, but enhanced the effect of docetaxel on tumor .
体外研究：
EL-102 (0-120 nM; 72 h) inhibits prostate cancer cells proliferation in vitro.EL-102 (0-100 nM; 72 h) shows cytotoxicity to prostate cancer cell lines.EL-102 (10-100 nM; 24-72 h) induces cellular apoptosis and affects cell cycle.EL-102 (10-100 nM; 24-48 h) affects PARP cleavage in DU145 cells.EL-102 (5 nM; 0-60 min) inhibits tubulin polymerisation activity.EL-102 (0-100 nM; 1 hour) inhibits Hif1α protein expression.
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