产品
编 号：F085053
分子式：C13H20N4O2S
分子量：296.39
分子式：C13H20N4O2S
分子量：296.39
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 1234569-09-5
产品详情
生物活性：
Lalistat 2 is an inhibitor of many lipases especially Lysosomal acid lipase (LAL, IC50 = 152 nM), which is a key enzyme that degrades neutral lipids at an acidic pH in lysosomes. Lalistat 2 is commonly used to investigate the cell-specific functions of LAL and LAL deficiency in vitro, as well as specifically measure LAL activity in human blood samples or cells .
体外研究：
Lalistat 2 (30 μM, 7 d) 不影响小鼠脂肪细胞的分化，但减少异丙肾上腺素刺激的脂肪分解。Lalistat 2 (30 μM, 7 d) 抑制小鼠脂肪细胞内中性脂质水解酶的活性。Lalistat 2 (0.1-100 μM, 20 h) 剂量依赖性地抑制骨髓源性巨噬细胞 (BMDM) 内的中性脂质水解酶。Lalistat 2 (30 μM, 24 h) 抑制小鼠和人 COS-7 细胞中的脂肪甘油三酯脂肪酶和激素敏感性脂肪酶。Lalistat 2 (30 μM, 20 h) 可降低小鼠骨髓来源巨噬细胞中 LAL、ATGL、HSL、MGL、PNPLA6 和 NCEH1 的活性。
Lalistat 2 is an inhibitor of many lipases especially Lysosomal acid lipase (LAL, IC50 = 152 nM), which is a key enzyme that degrades neutral lipids at an acidic pH in lysosomes. Lalistat 2 is commonly used to investigate the cell-specific functions of LAL and LAL deficiency in vitro, as well as specifically measure LAL activity in human blood samples or cells .
体外研究：
Lalistat 2 (30 μM, 7 d) 不影响小鼠脂肪细胞的分化，但减少异丙肾上腺素刺激的脂肪分解。Lalistat 2 (30 μM, 7 d) 抑制小鼠脂肪细胞内中性脂质水解酶的活性。Lalistat 2 (0.1-100 μM, 20 h) 剂量依赖性地抑制骨髓源性巨噬细胞 (BMDM) 内的中性脂质水解酶。Lalistat 2 (30 μM, 24 h) 抑制小鼠和人 COS-7 细胞中的脂肪甘油三酯脂肪酶和激素敏感性脂肪酶。Lalistat 2 (30 μM, 20 h) 可降低小鼠骨髓来源巨噬细胞中 LAL、ATGL、HSL、MGL、PNPLA6 和 NCEH1 的活性。
产品资料
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