生物活性：
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment.

体内活性：
测试了 (S)-10-Hydroxycamptothecin (10-Hydroxycamptothecin) 对小鼠 L1210 白血病的作用。在最佳剂量 (15 mg/kg) 下，(S)-10-Hydroxycamptothecin 可使寿命 (ILS) 延长 71%。

体外活性：
(S)-10-Hydroxycamptothecin (5-20 μg/L; 6 days; Hep G2 cells) 处理导致细胞周期停滞在 G2/M 期。 (S)-10-Hydroxycamptothecin 诱导分化、下调核抗原 (PCNA) 并上调 Hep G2 细胞中的野生型蛋白 p53。 (S)-10-Hydroxycamptothecin 抑制 L1210 白血病细胞，IC50 为 1.15 μM。