产品
编 号：F763557
分子式：C20H21F2N3O4S
分子量：437.46
分子式：C20H21F2N3O4S
分子量：437.46
产品类型
规格
价格
是否有货
10mM * 1mL in DMSO
766
In-stock
5mg
697
In-stock
10mg
1110
In-stock
25mg
1677
In-stock
50mg
2835
In-stock
结构图
CAS No: 3026500-20-6
产品详情
生物活性：
VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC50 of 0.1316 µM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers.
体外活性：
VVD-214 抑制细胞 HCT-116 和 SW480 生长，GI50 为 0.043 µM 和 23.45 µM。
VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC50 of 0.1316 µM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers.
体外活性：
VVD-214 抑制细胞 HCT-116 和 SW480 生长，GI50 为 0.043 µM 和 23.45 µM。
产品资料
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