产品
编 号：F096151
分子式：C24H38O3
分子量：374.56
分子式：C24H38O3
分子量：374.56
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1253909-57-7
产品详情
生物活性：
Icosabutate, an orally active ω-3 polyunsaturated fatty acid, is an aeicosapentaenoic acid (EPA) derivative. Icosabutate overcomes the drawbacks of unmodified EPA for liver targeting and improves insulin sensitivity, hepatic inflammation and fibrosis. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persistent?hypertriglyceridemia?.
体内研究：
Icosabutate (oral gavage; 100 mg/kg; once) accounts for the much higher flow rate of portal vein plasma (522?mL/h) versus mesenteric lymph (0.5?mL/h), that data demonstate thaticosabutate is almost entirely taken up through the portal vein (>99%) with only a small fraction of icosabutate being absorbed through the lymphatic pathway in 8‐week old male Wistar rats.Icosabutate ([14‐C]‐icosabutate; oral gavage; 100 mg/kg; once) shows that peak concentrations of radioactivity in most tissues at 4‐8 hours after the dose (except the gastrointestinal tract) with highest concentrations in the liver and kidney, most other tissues contain levels of radioactivity below that in plasma in male albino Wistar rats.Icosabutate (diet administration; 135?mg/kg/day; 5?weeks) markedly improved glucose tolerance after an oral glucose load, significantly reduces AUC (0‐120 minutes) by 60% without affecting body weight, decrease plasma alanine aminotransferase (ALT) levels improves glucose metabolism by a significant decrease in blood glucose, blood hemoglobin A1c, plasma insulin, and HOMA‐IR (-50%, -47%, -76% and -87%, respectively) in mice. Icosabutate (oral adminstration; 112?mg/kg/day; 20 weeks) prevents microvesicular steatosis (-35%) and hepatocellular hypertrophy (-82%), but not macrovesicular steatosis. After 20 weeks of treatment, despite comparable decreases in hepatic inflammatory cell aggregates, only icosabutate reduced hepatic collagen content.Animal Model:6‐8‐week‐old male?ob/ob?mice
Dosage:135?mg/kg
Administration:135?mg/kg/day through diet administration; 5?weeks
Result:Improved glucose metabolism and insulin resistance.
Animal Model:8‐15‐week‐old male APOE*3Leiden.CETP mice fed a high‐fat and high cholesterol diet
Dosage:112?mg/kg/day
Administration:Oral gavage; 20 weeks
Result:Improved microvesicular steatosis, hepatic inflammation, and fibrosis.
Icosabutate, an orally active ω-3 polyunsaturated fatty acid, is an aeicosapentaenoic acid (EPA) derivative. Icosabutate overcomes the drawbacks of unmodified EPA for liver targeting and improves insulin sensitivity, hepatic inflammation and fibrosis. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persistent?hypertriglyceridemia?.
体内研究：
Icosabutate (oral gavage; 100 mg/kg; once) accounts for the much higher flow rate of portal vein plasma (522?mL/h) versus mesenteric lymph (0.5?mL/h), that data demonstate thaticosabutate is almost entirely taken up through the portal vein (>99%) with only a small fraction of icosabutate being absorbed through the lymphatic pathway in 8‐week old male Wistar rats.Icosabutate ([14‐C]‐icosabutate; oral gavage; 100 mg/kg; once) shows that peak concentrations of radioactivity in most tissues at 4‐8 hours after the dose (except the gastrointestinal tract) with highest concentrations in the liver and kidney, most other tissues contain levels of radioactivity below that in plasma in male albino Wistar rats.Icosabutate (diet administration; 135?mg/kg/day; 5?weeks) markedly improved glucose tolerance after an oral glucose load, significantly reduces AUC (0‐120 minutes) by 60% without affecting body weight, decrease plasma alanine aminotransferase (ALT) levels improves glucose metabolism by a significant decrease in blood glucose, blood hemoglobin A1c, plasma insulin, and HOMA‐IR (-50%, -47%, -76% and -87%, respectively) in mice. Icosabutate (oral adminstration; 112?mg/kg/day; 20 weeks) prevents microvesicular steatosis (-35%) and hepatocellular hypertrophy (-82%), but not macrovesicular steatosis. After 20 weeks of treatment, despite comparable decreases in hepatic inflammatory cell aggregates, only icosabutate reduced hepatic collagen content.Animal Model:6‐8‐week‐old male?ob/ob?mice
Dosage:135?mg/kg
Administration:135?mg/kg/day through diet administration; 5?weeks
Result:Improved glucose metabolism and insulin resistance.
Animal Model:8‐15‐week‐old male APOE*3Leiden.CETP mice fed a high‐fat and high cholesterol diet
Dosage:112?mg/kg/day
Administration:Oral gavage; 20 weeks
Result:Improved microvesicular steatosis, hepatic inflammation, and fibrosis.
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