产品
编 号：F096453
分子式：C23H25F3N4
分子量：414.47
分子式：C23H25F3N4
分子量：414.47
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 1254980-38-5
产品详情
生物活性：
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50?= 7.71).
体外研究：
JNJ‐4628122 binds to the selected mGlu2?receptor mutants is significantly decreased by approximately 10‐fold compared with WT, in transfected mGlu2?WT and mutant receptors in CHO‐K1 cells, mutations F643A and N735D are selected.
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50?= 7.71).
体外研究：
JNJ‐4628122 binds to the selected mGlu2?receptor mutants is significantly decreased by approximately 10‐fold compared with WT, in transfected mGlu2?WT and mutant receptors in CHO‐K1 cells, mutations F643A and N735D are selected.
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