产品
编 号：F100950
分子式：C22H23F2N5O
分子量：411.45
分子式：C22H23F2N5O
分子量：411.45
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CAS No: 1261113-96-5
产品详情
生物活性：
Ganaplacide (KAF156) is a first-in-class,orally active imidazolopiperazine antimalarial agent.Ganaplacide is active against a broad range of Plasmodiumspecies, including drug-resistant parasites. Ganaplacide is parasiticidalagainst both asexual and sexual blood stages as well as the liver stages of theparasite.
体内研究：
Ganaplacide (KAF156) (1-15 mg/kg; p.o.) is fully protective in a causal prophylactic mouse model of malaria.Ganaplacide (KAF156) 对成熟的恶性疟原虫配子细胞表现出杀灭活性，从而阻止寄生虫传播给按蚊。Animal Model:Mice (causal prophylactic rodent malaria model)
Dosage:1-15 mg/kg
Administration:p.o.
Result:A single oral dose of 10 mg of KAF156/kg administered 2 h before infection was fully protective.
体外研究：
Ganaplacide (KAF156) 对恶性疟原虫药物敏感和耐药菌株具有杀血裂殖活性，50% 抑制浓度为 6 至 17.4 nM。
Ganaplacide (KAF156) is a first-in-class,orally active imidazolopiperazine antimalarial agent.Ganaplacide is active against a broad range of Plasmodiumspecies, including drug-resistant parasites. Ganaplacide is parasiticidalagainst both asexual and sexual blood stages as well as the liver stages of theparasite.
体内研究：
Ganaplacide (KAF156) (1-15 mg/kg; p.o.) is fully protective in a causal prophylactic mouse model of malaria.Ganaplacide (KAF156) 对成熟的恶性疟原虫配子细胞表现出杀灭活性，从而阻止寄生虫传播给按蚊。Animal Model:Mice (causal prophylactic rodent malaria model)
Dosage:1-15 mg/kg
Administration:p.o.
Result:A single oral dose of 10 mg of KAF156/kg administered 2 h before infection was fully protective.
体外研究：
Ganaplacide (KAF156) 对恶性疟原虫药物敏感和耐药菌株具有杀血裂殖活性，50% 抑制浓度为 6 至 17.4 nM。
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