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编 号:F106229
分子式:C58H105N16Na5O28S5
分子量:1749.82
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生物活性:
Colistimethate is a polymyxin with cytotoxicity to renal tubular cells. Colistimethate has poorly inactive in vivo. Colistimethate shows seldomly detectable activity against 6 strains of P. aeruginosa.

体内研究:
Colistimethate is prone to cause nephrotoxicity in vivo. Colistimethate (306 mg/kg; s.c.; single dose) is relatively ineffective against P. aeruginosa strains (i.p.) in mouse.

体外研究:
Colistimethate is cytotoxic to renal tubular cells.
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