产品
编 号：F106920
分子式：C21H21ClN2O8
分子量：464.85
分子式：C21H21ClN2O8
分子量：464.85
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 127-33-3
产品详情
生物活性：
Demeclocycline is an orally active tetracycline antibiotic. Demeclocycline impairs protein synthesis by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA. Demeclocycline shows anti-bacterial activitise to a wide variety of bacterial infections.
体内研究：
Demeclocycline (Intraperitoneal injection; 40 mg/kg; once daily; 48 h) treatment results in a significant reduction of hyponatremia and a significant correction of the hypoosmolality, and is not nephrotoxic.Animal Model:Male Wistar rats induced with hyponatremia
Dosage:40 mg/kg
Administration:Intraperitoneal injection; 40 mg/kg; once daily; 48 hours
Result:Increased urine volume, decreased urine osmolality, and caused a significantly increased fractional excretion of water.
Animal Model:Male Wistar rats induced with hyponatremia
Dosage:40 mg/kg
Administration:Intraperitoneal injection; 40 mg/kg; once daily; 48 hours
Result:Indicated the effect in the renal inner medulla for AQP2 and AC5/6 specifically, and not secondary toxicity effect.
体外研究：
Demeclocycline (0-100 μM; 24 h) treatment reduces AQP2 abundance in mpkCCD cells.Demeclocycline (10 μM; 24 h) treatment promotes the activity of monocytes and macrophages.Demeclocycline (1-10 μM; 72 h) treatment directly affects the growth of brain tumorinitiating cells.
Demeclocycline is an orally active tetracycline antibiotic. Demeclocycline impairs protein synthesis by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA. Demeclocycline shows anti-bacterial activitise to a wide variety of bacterial infections.
体内研究：
Demeclocycline (Intraperitoneal injection; 40 mg/kg; once daily; 48 h) treatment results in a significant reduction of hyponatremia and a significant correction of the hypoosmolality, and is not nephrotoxic.Animal Model:Male Wistar rats induced with hyponatremia
Dosage:40 mg/kg
Administration:Intraperitoneal injection; 40 mg/kg; once daily; 48 hours
Result:Increased urine volume, decreased urine osmolality, and caused a significantly increased fractional excretion of water.
Animal Model:Male Wistar rats induced with hyponatremia
Dosage:40 mg/kg
Administration:Intraperitoneal injection; 40 mg/kg; once daily; 48 hours
Result:Indicated the effect in the renal inner medulla for AQP2 and AC5/6 specifically, and not secondary toxicity effect.
体外研究：
Demeclocycline (0-100 μM; 24 h) treatment reduces AQP2 abundance in mpkCCD cells.Demeclocycline (10 μM; 24 h) treatment promotes the activity of monocytes and macrophages.Demeclocycline (1-10 μM; 72 h) treatment directly affects the growth of brain tumorinitiating cells.
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