产品
编 号：F107830
分子式：C15H11FN4O2S
分子量：330.34
分子式：C15H11FN4O2S
分子量：330.34
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CAS No: 1276617-62-9
产品详情
生物活性：
VU0409106 is a potent and selective mGlu5 negative allosteric modulator (NAM) with an IC50 of 24 nM. VU0409106 shows anxiolytic effects in rat models in a concentration-dependent manner. VU0409106 also penetrates the blood-brain barrier (BBB).
体内研究：
VU0409106 (10 mg/kg; i.p.; once) penetrates the blood-brain barrier (BBB) and demonstrates good brain to plasma ratio that near unity.Animal Model:CD-1 mice
Dosage:10 mg/kg (10% Tween 80 formulation)
Administration:Intraperitoneal injection.
Result:1.19Pharmacokinetic Parameters of VU0409106 in CD-1 mice.IP (10 mg/kg)
Plasma Tmax (h)0.25
Plasma Cmax (ng/mL)1450
Brain Tmax (h)0.25
Brain Cmax (ng/mL)1350
AUCplasma (ng/mL?h)702
AUCbrain (ng/mL?h)696
B/P ratio0.99
VU0409106 is a potent and selective mGlu5 negative allosteric modulator (NAM) with an IC50 of 24 nM. VU0409106 shows anxiolytic effects in rat models in a concentration-dependent manner. VU0409106 also penetrates the blood-brain barrier (BBB).
体内研究：
VU0409106 (10 mg/kg; i.p.; once) penetrates the blood-brain barrier (BBB) and demonstrates good brain to plasma ratio that near unity.Animal Model:CD-1 mice
Dosage:10 mg/kg (10% Tween 80 formulation)
Administration:Intraperitoneal injection.
Result:1.19Pharmacokinetic Parameters of VU0409106 in CD-1 mice.IP (10 mg/kg)
Plasma Tmax (h)0.25
Plasma Cmax (ng/mL)1450
Brain Tmax (h)0.25
Brain Cmax (ng/mL)1350
AUCplasma (ng/mL?h)702
AUCbrain (ng/mL?h)696
B/P ratio0.99
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