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编 号：F108370
分子式：C23H19N3O5
分子量：417.41
分子式：C23H19N3O5
分子量：417.41
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CAS No: 1279698-31-5
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生物活性：
QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects.
体内研究：
QTX125 (60 mg/kg; i.p.; daily dosing for 5 days; for 4 weeks) treatment inhibits tumor growth in REC-1 or MINO cells xenografted in nude mice.Animal Model:Nude mice bearing REC-1 or MINO cells
Dosage:60 mg/kg
Administration:Intraperitoneal administration; daily dosing for 5 days; for 4 weeks
Result:Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice.
体外研究：
QTX125 (25-500 nM; 24-48 hours) treatment induces the subsequent apoptosis demonstrated by annexin V/propidium iodide double staining and the cleavage of caspase-9, caspase-8, caspase-3, and PARP. In MCL cell lines MINO, REC-1, IRM-2 and HBL-2 cells, QTX125 (10 nM, 10 μM, 100 μM) induces dose-dependent hyperacetylation of α-tubulin.QTX125 has the strongest growth-inhibitory effect in Burkitt cell lymphoma, follicular lymphoma, and mantle cell lymphoma (MCL).
QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects.
体内研究：
QTX125 (60 mg/kg; i.p.; daily dosing for 5 days; for 4 weeks) treatment inhibits tumor growth in REC-1 or MINO cells xenografted in nude mice.Animal Model:Nude mice bearing REC-1 or MINO cells
Dosage:60 mg/kg
Administration:Intraperitoneal administration; daily dosing for 5 days; for 4 weeks
Result:Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice.
体外研究：
QTX125 (25-500 nM; 24-48 hours) treatment induces the subsequent apoptosis demonstrated by annexin V/propidium iodide double staining and the cleavage of caspase-9, caspase-8, caspase-3, and PARP. In MCL cell lines MINO, REC-1, IRM-2 and HBL-2 cells, QTX125 (10 nM, 10 μM, 100 μM) induces dose-dependent hyperacetylation of α-tubulin.QTX125 has the strongest growth-inhibitory effect in Burkitt cell lymphoma, follicular lymphoma, and mantle cell lymphoma (MCL).
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