产品
编 号：F109339
分子式：C23H28N2O3S
分子量：412.55
分子式：C23H28N2O3S
分子量：412.55
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CAS No: 128312-51-6
产品详情
生物活性：
Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be used for the research of asthma.
体内研究：
Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD50s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively.Animal Model:Guinea pigs
Dosage:10 mg/kg
Administration:Oral gavage; 10 mg/kg once
Result:Inhibited LTD4-induced bronchoconstnction and antigen-induced bronchoconstnction in guinea pigs.
体外研究：
Ro 24-5913 competes with [3H]LTD4 for its binding site in guinea pig lung membranes with an IC50 value of 6.4 nM.Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pKB value of 9.3.
Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be used for the research of asthma.
体内研究：
Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD50s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively.Animal Model:Guinea pigs
Dosage:10 mg/kg
Administration:Oral gavage; 10 mg/kg once
Result:Inhibited LTD4-induced bronchoconstnction and antigen-induced bronchoconstnction in guinea pigs.
体外研究：
Ro 24-5913 competes with [3H]LTD4 for its binding site in guinea pig lung membranes with an IC50 value of 6.4 nM.Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pKB value of 9.3.
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