产品
编 号：F111842
分子式：C25H26O6
分子量：422.47
分子式：C25H26O6
分子量：422.47
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 129280-34-8
产品详情
生物活性：
Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death.
体内研究：
Isoangustone A (2 or 10 mg/kg; i.p.; daily for 35 days) 显著降低小鼠 SK-MEL-28 异种移植物的肿瘤生长、体积和重量。Animal Model:Male Balb/c nu/nu mice, SK-MEL-28 xenograft model
Dosage:2 or 10 mg/kg
Administration:Intraperitoneal injection, daily for 35 days
Result:Significantly suppressed tumor weight compared to the control group. Markedly inhibited the expression of proliferating cell nuclear antigen (PCNA). Decreased phosphorylation levels of Akt.
体外研究：
Isoangustone A (10 and 20 μM; 48 and 72 h) 抑制 SK-MEL-28 细胞增殖并诱导 G1 期细胞周期阻滞。Isoangustone A (10 and 20 μM; 48 h) 通过 Akt/GSK3β 和 MKK4/MKK7/JNKs 信号通路介导 G1 期相关蛋白的丰度降低。Isoangustone A 通过 ATP 竞争方式直接结合抑制 PI3-K、MKK4 和 MKK7 激酶活性。Isoangustone A (20 μM; 0.5-4 h) 通过激活 AMPK 信号诱导结直肠癌细胞自噬。Isoangustone A (1-20 μM; 0-100 min) 抑制线粒体呼吸。Isoangustone A (15 μM; 6 h) 诱导 SW480 细胞凋亡。Isoangustone A (1-20 μΜ; 3 days) 抑制人肾系膜细胞的纤维化和炎症。
Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death.
体内研究：
Isoangustone A (2 or 10 mg/kg; i.p.; daily for 35 days) 显著降低小鼠 SK-MEL-28 异种移植物的肿瘤生长、体积和重量。Animal Model:Male Balb/c nu/nu mice, SK-MEL-28 xenograft model
Dosage:2 or 10 mg/kg
Administration:Intraperitoneal injection, daily for 35 days
Result:Significantly suppressed tumor weight compared to the control group. Markedly inhibited the expression of proliferating cell nuclear antigen (PCNA). Decreased phosphorylation levels of Akt.
体外研究：
Isoangustone A (10 and 20 μM; 48 and 72 h) 抑制 SK-MEL-28 细胞增殖并诱导 G1 期细胞周期阻滞。Isoangustone A (10 and 20 μM; 48 h) 通过 Akt/GSK3β 和 MKK4/MKK7/JNKs 信号通路介导 G1 期相关蛋白的丰度降低。Isoangustone A 通过 ATP 竞争方式直接结合抑制 PI3-K、MKK4 和 MKK7 激酶活性。Isoangustone A (20 μM; 0.5-4 h) 通过激活 AMPK 信号诱导结直肠癌细胞自噬。Isoangustone A (1-20 μM; 0-100 min) 抑制线粒体呼吸。Isoangustone A (15 μM; 6 h) 诱导 SW480 细胞凋亡。Isoangustone A (1-20 μΜ; 3 days) 抑制人肾系膜细胞的纤维化和炎症。
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