产品
编 号：F112377
分子式：C16H15ClN5O5PS2
分子量：487.88
分子式：C16H15ClN5O5PS2
分子量：487.88
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CAS No: 129693-13-6
产品详情
生物活性：
Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold.
体外研究：
Sp-8-CPT-cAMPS (100 μM; 24 h) enhances the IL-1β-stimulated nitrite release, and increases the release ofnitrite by vascular smooth muscle cells by 3 fold in the absence of IL-1β in vascular smooth muscle cells.Sp-8-CPT-cAMPS (100 μM; 24 h) increases IL-1β-induced expression of iNOS protein in rat aortic smooth muscle cells.Sp-8-CPT-cAMPS (10?μM; 30?min) exhibits anti-spasmogenic activity on ACh-induced tension development in guinea-pig trachealis.
Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold.
体外研究：
Sp-8-CPT-cAMPS (100 μM; 24 h) enhances the IL-1β-stimulated nitrite release, and increases the release ofnitrite by vascular smooth muscle cells by 3 fold in the absence of IL-1β in vascular smooth muscle cells.Sp-8-CPT-cAMPS (100 μM; 24 h) increases IL-1β-induced expression of iNOS protein in rat aortic smooth muscle cells.Sp-8-CPT-cAMPS (10?μM; 30?min) exhibits anti-spasmogenic activity on ACh-induced tension development in guinea-pig trachealis.
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