产品
编 号：F112406
分子式：C23H27Cl2N3O2
分子量：448.39
分子式：C23H27Cl2N3O2
分子量：448.39
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
427
In-stock
200mg
592
In-stock
结构图
CAS No: 129722-12-9
产品详情
生物活性：
Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19.
体内研究：
Aripiprazole (0-3 mg/kg, IP, daily) shows some anxiolytic properties.Animal Model:WAG/Rij rats (N = 6 per dose, 6 months, administration of a mixture of tiletamine/zolazepam)
Dosage:0, 0.3, 1, 3 mg/kg
Administration:IP, 1 mL/kg, every day at 5 p.m. until the end of the experiments
Result:Showed some anxiolytic properties with the 1 mg/kg dose being the most active.
体外研究：
Aripiprazole potently activates D2 receptor-mediated inhibition of cAMP accumulation.Aripiprazole shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine.
Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19.
体内研究：
Aripiprazole (0-3 mg/kg, IP, daily) shows some anxiolytic properties.Animal Model:WAG/Rij rats (N = 6 per dose, 6 months, administration of a mixture of tiletamine/zolazepam)
Dosage:0, 0.3, 1, 3 mg/kg
Administration:IP, 1 mL/kg, every day at 5 p.m. until the end of the experiments
Result:Showed some anxiolytic properties with the 1 mg/kg dose being the most active.
体外研究：
Aripiprazole potently activates D2 receptor-mediated inhibition of cAMP accumulation.Aripiprazole shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine.
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