产品
编 号：F114588
分子式：C22H23ClF2N4O2S
分子量：480.96
分子式：C22H23ClF2N4O2S
分子量：480.96
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 1307245-86-8
产品详情
生物活性：
LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models.
体内研究：
LY2940094 (3、10 或 30 mg/kg；2-3 mL/kg；每天口服；持续 4 天) 剂量依赖性地减少印第安纳州酒精偏好 (P) 和马尔基吉安撒丁岛酒精偏好 (msP) 大鼠，不影响食物/水的摄入或运动活动。Animal Model:Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)
Dosage:3, 10, or 30 mg/kg; 2-3 mL/kg
Administration:Administered orally; daily; 4 days
Result:Reduced homecage ethanol self-administration.
LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models.
体内研究：
LY2940094 (3、10 或 30 mg/kg；2-3 mL/kg；每天口服；持续 4 天) 剂量依赖性地减少印第安纳州酒精偏好 (P) 和马尔基吉安撒丁岛酒精偏好 (msP) 大鼠，不影响食物/水的摄入或运动活动。Animal Model:Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)
Dosage:3, 10, or 30 mg/kg; 2-3 mL/kg
Administration:Administered orally; daily; 4 days
Result:Reduced homecage ethanol self-administration.
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