产品
编 号：F116659
分子式：C33H48N8O2
分子量：588.79
分子式：C33H48N8O2
分子量：588.79
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 1311982-88-3
产品详情
生物活性：
MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively. MIR96-IN-1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
体外研究：
MIR96-IN-1 (Compound 1) selectively inhibits production of mature miR-96 and triggers apoptosis in breast cancer cells at micromolar concentrations.MIR96-IN-1 (Compound 3) binds a UU loop in miR-96 and inhibits its biogenesis.
MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively. MIR96-IN-1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
体外研究：
MIR96-IN-1 (Compound 1) selectively inhibits production of mature miR-96 and triggers apoptosis in breast cancer cells at micromolar concentrations.MIR96-IN-1 (Compound 3) binds a UU loop in miR-96 and inhibits its biogenesis.
产品资料
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