产品
编 号：F123928
分子式：C16H12N2O3
分子量：280.28
分子式：C16H12N2O3
分子量：280.28
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
360
In-stock
10mg
608
In-stock
25mg
1224
In-stock
50mg
2032
In-stock
100mg
3376
In-stock
结构图
CAS No: 133550-35-3
产品详情
生物活性：
AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis.
体外研究：
In DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis.AG-494 significantly prevents NF-kB activation in silica-stimulated cells, and also reduces NF-kB activation in H2O2-treated cells.AG-494 (3-9 μM; 5-7 days) inhibits BMP9-induced ALP activity in a dose-dependent manner.
AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis.
体外研究：
In DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis.AG-494 significantly prevents NF-kB activation in silica-stimulated cells, and also reduces NF-kB activation in H2O2-treated cells.AG-494 (3-9 μM; 5-7 days) inhibits BMP9-induced ALP activity in a dose-dependent manner.
产品资料
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