产品
编 号：F129845
分子式：C26H20ClN3O5
分子量：489.91
分子式：C26H20ClN3O5
分子量：489.91
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 1346607-05-3
产品详情
生物活性：
GSK621 is a specific AMPK activator, with IC50 values of 13-30 μM for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation.
体内研究：
GSK621 (30 mg/kg, ip twice daily) exhibits significant anti-tumor activity in MOLM-14 cells xenograft.Animal Model:MOLM-14 cells xenografted into nude mice.
Dosage:30 mg/kg.
Administration:IP twice daily.
Result:Reduced leukemia growth and significantly extended survival compared to vehicle-treated animals or those treated with 10 mg/kg twice daily.
体外研究：
GSK621 (30 μM) induces AMPKα T172, ACC (S79) and ULK1 (S555) phosphorylation.GSK621 (30 μM) induces autophagy and apoptosis.GSK621 treatment also induces PERK phosphorylation, a marker of ER stress, in AML cells.
GSK621 is a specific AMPK activator, with IC50 values of 13-30 μM for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation.
体内研究：
GSK621 (30 mg/kg, ip twice daily) exhibits significant anti-tumor activity in MOLM-14 cells xenograft.Animal Model:MOLM-14 cells xenografted into nude mice.
Dosage:30 mg/kg.
Administration:IP twice daily.
Result:Reduced leukemia growth and significantly extended survival compared to vehicle-treated animals or those treated with 10 mg/kg twice daily.
体外研究：
GSK621 (30 μM) induces AMPKα T172, ACC (S79) and ULK1 (S555) phosphorylation.GSK621 (30 μM) induces autophagy and apoptosis.GSK621 treatment also induces PERK phosphorylation, a marker of ER stress, in AML cells.
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