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编 号：F132628
分子式：C20H33NO3S
分子量：367.55
分子式：C20H33NO3S
分子量：367.55
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CAS No: 135304-07-3
产品详情
生物活性：
Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site.
体内研究：
Arazine (AFC) (2,000?μg/20?μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED50) of 55±12?μg/20?μl.Animal Model:TPA-induced ear acute inflammation in mouse
Dosage:2000?μg/20?μl
Administration:2000?μg/20?μl; Applied on ear
Result:Inhibited ear edema, as measured by ear weight.
体外研究：
Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner inHMEC-1 cell.Arazine (10–100 μM;8 hours)significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion inHMEC-1 cell.
Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site.
体内研究：
Arazine (AFC) (2,000?μg/20?μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED50) of 55±12?μg/20?μl.Animal Model:TPA-induced ear acute inflammation in mouse
Dosage:2000?μg/20?μl
Administration:2000?μg/20?μl; Applied on ear
Result:Inhibited ear edema, as measured by ear weight.
体外研究：
Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner inHMEC-1 cell.Arazine (10–100 μM;8 hours)significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion inHMEC-1 cell.
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