产品
编 号：F134664
分子式：C10H11ClN4
分子量：222.68
分子式：C10H11ClN4
分子量：222.68
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
440
In-stock
结构图
CAS No: 135410-20-7
产品详情
生物活性：
Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders.
体内研究：
Acetamiprid decreases in body weight and mildly affected spermatogenesis. .Acetamiprid decreases the expression of testosterone-metabolism genes, nAChR subunit genes, and proliferation-associated genes in mice.Acetamiprid disrupts subsequent testosterone biosynthesis by decreasing the rate of conversion of cholesterol to testosterone and by preventing cholesterol from entering the mitochondria within the Leydig cells. These effects caused reproductive damage to the rats.Animal Model:Male Sprague Dawley (SD) rats
Dosage:10 mg/kg, 30 mg/kg
Administration:Oral gavage; daily; for 35 days
Result:Inhibited testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells.
Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders.
体内研究：
Acetamiprid decreases in body weight and mildly affected spermatogenesis. .Acetamiprid decreases the expression of testosterone-metabolism genes, nAChR subunit genes, and proliferation-associated genes in mice.Acetamiprid disrupts subsequent testosterone biosynthesis by decreasing the rate of conversion of cholesterol to testosterone and by preventing cholesterol from entering the mitochondria within the Leydig cells. These effects caused reproductive damage to the rats.Animal Model:Male Sprague Dawley (SD) rats
Dosage:10 mg/kg, 30 mg/kg
Administration:Oral gavage; daily; for 35 days
Result:Inhibited testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells.
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