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编 号：F135769
分子式：C27H32N6O3
分子量：488.58
分子式：C27H32N6O3
分子量：488.58
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CAS No: 1355244-02-8
产品详情
生物活性：
ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively.
体外研究：
ML 190 exhibits plasma protein binding of 93.96% (1 μM), 88.54% (10 μM) in human and88.46% (1 μM), 80.07% (10 μM) in mouse, respectively; plasma remaining percents of 100% at 3 hours in both human and mouse; hepatic microsome remaining percents of 22.13% and 7.34% at 1 hour in human and mouse, respectively; and hepatic toxicity LC50 over 50 μM.
ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively.
体外研究：
ML 190 exhibits plasma protein binding of 93.96% (1 μM), 88.54% (10 μM) in human and88.46% (1 μM), 80.07% (10 μM) in mouse, respectively; plasma remaining percents of 100% at 3 hours in both human and mouse; hepatic microsome remaining percents of 22.13% and 7.34% at 1 hour in human and mouse, respectively; and hepatic toxicity LC50 over 50 μM.
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