产品
编 号：F137958
分子式：C24H28N2O4
分子量：408.49
分子式：C24H28N2O4
分子量：408.49
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 136152-65-3
产品详情
生物活性：
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).
体外研究：
(S)-(+)-Dimethindene maleate (2 μM；1 小时) 显著削弱小鼠扩展多能干细胞 (mEPS) 细胞在嵌合囊胚中的发育潜能，并导致引物人多能干细胞 (hPSC) 转化为 hEPS 细胞的快速分化。
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).
体外研究：
(S)-(+)-Dimethindene maleate (2 μM；1 小时) 显著削弱小鼠扩展多能干细胞 (mEPS) 细胞在嵌合囊胚中的发育潜能，并导致引物人多能干细胞 (hPSC) 转化为 hEPS 细胞的快速分化。
产品资料
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