产品
编 号：F141985
分子式：C23H30F3N5O4S
分子量：529.58
分子式：C23H30F3N5O4S
分子量：529.58
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
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10mg
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结构图
CAS No: 1374006-96-8
产品详情
生物活性：
ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency..
体内研究：
A single-dose pharmacokinetic (PK) study is performed in squirrel monkeys by oral (intragastric) delivery of ERDRP-0519 (50?mg/kg) and blood sampling at seven predefined time points after dosing. Serum concentrations peak ~2?h post-administration (Cmax=3.27?μM).
体外研究：
ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.07- 0.3 μM. ERDRP-0519 exhibits potency against MeV and related pathogens of the?Morbillivirus?genus, such as canine distemper virus (CDV).
ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency..
体内研究：
A single-dose pharmacokinetic (PK) study is performed in squirrel monkeys by oral (intragastric) delivery of ERDRP-0519 (50?mg/kg) and blood sampling at seven predefined time points after dosing. Serum concentrations peak ~2?h post-administration (Cmax=3.27?μM).
体外研究：
ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.07- 0.3 μM. ERDRP-0519 exhibits potency against MeV and related pathogens of the?Morbillivirus?genus, such as canine distemper virus (CDV).
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