产品
编 号：F144390
分子式：C25H36O4
分子量：400.55
分子式：C25H36O4
分子量：400.55
产品类型
规格
价格
是否有货
结构图
CAS No: 137945-48-3
产品详情
生物活性：
IP 751 is a synthetic orally available analogue of a metabolite of Δ9-tetrahydrocannabinol, acts as a cannabinoid receptor agonist, with Kis of 5.7 nM, 56.1 nM and EC50s of 11.6 nM, 13.4 nM for hCB1 and hCB2 receptors, respectively, and has anti-inflammatory property.
体内研究：
IP 751 (0.1-1 mg/kg, p.o.) causes reversal of hyperalgesia in a dose-dependent manner, with a maximal reversal of 63%, ED50 value of 0.5 mg/kg in a model of neuropathic pain in the rat, and a maximal reversal of 57%, ED50 value of 0.7 mg/kg in a model of inflammatory pain in the rat. However, IP 751 (1, 3, 10 mg/kg, p.o.) shows less potent in the tetrad tests than in the chronic pain models, with ED50s of 5.3 mg/kg, 2.3 mg/kg and 4.3 mg/kg in the rotarod, catalepsy and tail-flick assays, respectively.
体外研究：
IP 751 (CT-3; Ajulemic acid) is a synthetic analogue of a metabolite of Δ9-tetrahydrocannabinol, acts as a cannabinoid receptor agonist, with Kis of 5.7 nM, 56.1 nM and EC50s of 11.6 nM, 13.4 nM for hCB1 and hCB2 receptors, respectively, and has anti-inflammatory property.
IP 751 is a synthetic orally available analogue of a metabolite of Δ9-tetrahydrocannabinol, acts as a cannabinoid receptor agonist, with Kis of 5.7 nM, 56.1 nM and EC50s of 11.6 nM, 13.4 nM for hCB1 and hCB2 receptors, respectively, and has anti-inflammatory property.
体内研究：
IP 751 (0.1-1 mg/kg, p.o.) causes reversal of hyperalgesia in a dose-dependent manner, with a maximal reversal of 63%, ED50 value of 0.5 mg/kg in a model of neuropathic pain in the rat, and a maximal reversal of 57%, ED50 value of 0.7 mg/kg in a model of inflammatory pain in the rat. However, IP 751 (1, 3, 10 mg/kg, p.o.) shows less potent in the tetrad tests than in the chronic pain models, with ED50s of 5.3 mg/kg, 2.3 mg/kg and 4.3 mg/kg in the rotarod, catalepsy and tail-flick assays, respectively.
体外研究：
IP 751 (CT-3; Ajulemic acid) is a synthetic analogue of a metabolite of Δ9-tetrahydrocannabinol, acts as a cannabinoid receptor agonist, with Kis of 5.7 nM, 56.1 nM and EC50s of 11.6 nM, 13.4 nM for hCB1 and hCB2 receptors, respectively, and has anti-inflammatory property.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备