产品
编 号:F144542
分子式:C17H17NO3S
分子量:315.39
产品类型
结构图
CAS No: 13799-03-6
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产品详情
生物活性:
Protizinic acid is an orally active non-steroidal antiinflammatory agent with antiinflammatory and antipyretic activity. Protizinic acid inhibits phospholipase A2 (PLA2) activity, and the IC50 value is 210 μM.
体内研究:
In vivo leukokinin (LK) generation system using feline acute ischemia model, When 3 mg/kg Protizinic acid is injected twice intravenously to cats with acute cardiac ischemia, increased blood acid protease activity is inhibited and significant inhibitory action on the decrease of leukokininogen, the precursor of leukokinin, is observed.Oral administration of 30 mg/kg of Protizinic acid significantly inhibits arachidonic acid-induced erythema in guinea pigs.
体外研究:
Protizinic acid not only inhibits the in vitro generation of leukokinin but also antagonizes to it on the receptor site of leukokinin.