产品
编 号：F146922
分子式：C19H18F3N5O2S
分子量：437.44
分子式：C19H18F3N5O2S
分子量：437.44
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 1388651-30-6
产品详情
生物活性：
Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant BACE-1 inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research.
体内研究：
Elenbecestat (E2609; 0.3-30 mg/kg; p.o.) potently inhibits Ab1-40 and Ab1-42 production in the plasma and CSF of non-human primates.Elenbecestat displays the plasma half-life of 12-16 hours after once daily dosing.Animal Model:Cynomolgus monkeys (Pharmacokinetic analysis)
Dosage:0.3 mg/kg; 1 mg/kg; 3 mg/kg; 30 mg/kg
Administration:Oral administration
Result:Potently inhibits Ab1-40 and Ab1-42 production in the plasma and CSF.
体外研究：
Elenbecestat (E2609) is a potent BACE1 inhibitor with an IC50 of ~7 nmol/L in cell-based assay.Elenbecestat has been shown to reduce Ab production in the plasma, brain, and cerebrospinal fluid (CSF) of rodents.
Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant BACE-1 inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research.
体内研究：
Elenbecestat (E2609; 0.3-30 mg/kg; p.o.) potently inhibits Ab1-40 and Ab1-42 production in the plasma and CSF of non-human primates.Elenbecestat displays the plasma half-life of 12-16 hours after once daily dosing.Animal Model:Cynomolgus monkeys (Pharmacokinetic analysis)
Dosage:0.3 mg/kg; 1 mg/kg; 3 mg/kg; 30 mg/kg
Administration:Oral administration
Result:Potently inhibits Ab1-40 and Ab1-42 production in the plasma and CSF.
体外研究：
Elenbecestat (E2609) is a potent BACE1 inhibitor with an IC50 of ~7 nmol/L in cell-based assay.Elenbecestat has been shown to reduce Ab production in the plasma, brain, and cerebrospinal fluid (CSF) of rodents.
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