产品
编 号：F152408
分子式：C9H10N6O
分子量：218.22
分子式：C9H10N6O
分子量：218.22
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 140651-18-9
产品详情
生物活性：
CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. CAN508 exhibits a 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. Antitumor activity.
体内研究：
CAN508 (60 mg/kg; i.p.; daily for 10 days) has antitumor effects in esophageal adenocarcinoma xenografts.Animal Model:4 weeks-old female nude mice (esophageal adenocarcinoma xenografts)
Dosage:60 mg/kg
Administration:I.p.; daily for 10 days
Result:Caused reduction of tumor growth starting from post-treatment day three with 50.83% reduction.
体外研究：
CAN508 reduces the frequency of S-phase cells of the cancer cell line HT-29 in antiproliferation assays.CAN508 (20-40 μM; 72 hours) significantly reduces cell proliferation in a dose dependent manner in all three esophageal adenocarcinoma cell lines (SKGT4, OE33 and FLO-1 cells) with IC50s ranging from 34.99 to 91.09 μM.CAN508 (40 μM; 72 hours) increases apoptosis in all three esophageal adenocarcinoma cells.
CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. CAN508 exhibits a 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. Antitumor activity.
体内研究：
CAN508 (60 mg/kg; i.p.; daily for 10 days) has antitumor effects in esophageal adenocarcinoma xenografts.Animal Model:4 weeks-old female nude mice (esophageal adenocarcinoma xenografts)
Dosage:60 mg/kg
Administration:I.p.; daily for 10 days
Result:Caused reduction of tumor growth starting from post-treatment day three with 50.83% reduction.
体外研究：
CAN508 reduces the frequency of S-phase cells of the cancer cell line HT-29 in antiproliferation assays.CAN508 (20-40 μM; 72 hours) significantly reduces cell proliferation in a dose dependent manner in all three esophageal adenocarcinoma cell lines (SKGT4, OE33 and FLO-1 cells) with IC50s ranging from 34.99 to 91.09 μM.CAN508 (40 μM; 72 hours) increases apoptosis in all three esophageal adenocarcinoma cells.
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