产品
编 号：F154193
分子式：C17H30ClNO
分子量：299.88
分子式：C17H30ClNO
分子量：299.88
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 141545-89-3
产品详情
生物活性：
LY231617 is a potent and blood-brain barrier penetrable antioxidant. LY231617 is a neuroprotective agent in brain, it can be used for the research of nervous disease.
体内研究：
LY231617 (50 mg/kg; p.o. 30 minutes before occlusion) reduces global ischemic neuronal injury in rats.LY231617 (20 mg/kg; i.v. 30 minutes after occlusion) protects hippocampus and striatum from four-vessel occlusion.Animal Model:Male Wistar rats four-vessel occlusion
Dosage:50 mg/kg
Administration:Oral gavage; 50 mg/kg 30 minutes before occlusion
Result:Significantly protected both the hippocampus and striatum from 30 minutes of four-vessel occlusion.
Animal Model:Male Wistar rats four-vessel occlusion
Dosage:20 mg/kg
Administration:Intravenous injection ; 20 mg/kg 30 minutes after occlusion
Result:Significantly protected the hippocampus and the striatum when given 30 minutes after the onset of the ischemia at the time of reperfusion.
体外研究：
LY231617 (0.25, 1, 5, 10, and 25 μM; overnight) attenuates H2O2 toxicity to hippocampal cultures and shows the best effect at a concertration of 10 μM.LY231617 (5 μM; overnight) attenuates 8-isoprostane production and glutathione depletion.
LY231617 is a potent and blood-brain barrier penetrable antioxidant. LY231617 is a neuroprotective agent in brain, it can be used for the research of nervous disease.
体内研究：
LY231617 (50 mg/kg; p.o. 30 minutes before occlusion) reduces global ischemic neuronal injury in rats.LY231617 (20 mg/kg; i.v. 30 minutes after occlusion) protects hippocampus and striatum from four-vessel occlusion.Animal Model:Male Wistar rats four-vessel occlusion
Dosage:50 mg/kg
Administration:Oral gavage; 50 mg/kg 30 minutes before occlusion
Result:Significantly protected both the hippocampus and striatum from 30 minutes of four-vessel occlusion.
Animal Model:Male Wistar rats four-vessel occlusion
Dosage:20 mg/kg
Administration:Intravenous injection ; 20 mg/kg 30 minutes after occlusion
Result:Significantly protected the hippocampus and the striatum when given 30 minutes after the onset of the ischemia at the time of reperfusion.
体外研究：
LY231617 (0.25, 1, 5, 10, and 25 μM; overnight) attenuates H2O2 toxicity to hippocampal cultures and shows the best effect at a concertration of 10 μM.LY231617 (5 μM; overnight) attenuates 8-isoprostane production and glutathione depletion.
产品资料
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