产品
编 号：F154336
分子式：C21H22O9
分子量：418.39
分子式：C21H22O9
分子量：418.39
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
320
In-stock
100mg
480
In-stock
结构图
CAS No: 1415-73-2
产品详情
生物活性：
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI).
体内研究：
Aloin (10-30 mg/kg; 单剂量; TBI 损伤前 30 min 注射) 可改善小鼠受控制性皮质冲击损伤而引起的创伤性脑损伤 (TBI)。Aloin 在小鼠脑毛细血管内皮细胞中表现出抗氧化应激和抗凋亡特性。
体外研究：
Aloin (0.01-1 μM; 10 d) 以剂量依赖性方式增强成骨细胞分化基因、Bmp-2、Runx2 和胶原蛋白 1a 的表达。Aloin (0.05 μM; 10 d) 通过 MAPK 介导的 Wnt 和 Bmp 信号通路诱导 MC3T3-E1 细胞分化为成骨细胞。Aloin (0.05 μM; 10 d) 提高了 MC3T3-E1 细胞中 ALP 的活性。Aloin (10-80 μg/mL; 4.5 h) 通过减弱细胞内 ROS 的产生，抑制线粒体膜电位的变化，增加双轴拉伸损伤后的小鼠脑血管内皮细胞 (ECs) 的活力。
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI).
体内研究：
Aloin (10-30 mg/kg; 单剂量; TBI 损伤前 30 min 注射) 可改善小鼠受控制性皮质冲击损伤而引起的创伤性脑损伤 (TBI)。Aloin 在小鼠脑毛细血管内皮细胞中表现出抗氧化应激和抗凋亡特性。
体外研究：
Aloin (0.01-1 μM; 10 d) 以剂量依赖性方式增强成骨细胞分化基因、Bmp-2、Runx2 和胶原蛋白 1a 的表达。Aloin (0.05 μM; 10 d) 通过 MAPK 介导的 Wnt 和 Bmp 信号通路诱导 MC3T3-E1 细胞分化为成骨细胞。Aloin (0.05 μM; 10 d) 提高了 MC3T3-E1 细胞中 ALP 的活性。Aloin (10-80 μg/mL; 4.5 h) 通过减弱细胞内 ROS 的产生，抑制线粒体膜电位的变化，增加双轴拉伸损伤后的小鼠脑血管内皮细胞 (ECs) 的活力。
产品资料
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