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编 号：F162485
分子式：C54H110N36O10
分子量：1423.69
分子式：C54H110N36O10
分子量：1423.69
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CAS No: 143413-47-2
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生物活性：
(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
体内研究：
(Arg)9 (Nona-L-arginine; 1?μM/kg (600? μL); i.v.; once, for 30min; male Sprague–Dawley ratspermanent middle cerebral artery stroke model) shows neuroprotective effects and reduces infarct volume.Animal Model:Male Sprague–Dawley rats (270 to 320?g) permanent middle cerebral artery stroke model
Dosage:1 μM/kg (600? μL)
Administration:Intravenous injection; once, over 5 minutes
Result:Reduced significantiy 20% in infarct volume.
体外研究：
(Arg)9 (Nona-L-arginine; 5-10 μM) provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC50=6 μM).
(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
体内研究：
(Arg)9 (Nona-L-arginine; 1?μM/kg (600? μL); i.v.; once, for 30min; male Sprague–Dawley ratspermanent middle cerebral artery stroke model) shows neuroprotective effects and reduces infarct volume.Animal Model:Male Sprague–Dawley rats (270 to 320?g) permanent middle cerebral artery stroke model
Dosage:1 μM/kg (600? μL)
Administration:Intravenous injection; once, over 5 minutes
Result:Reduced significantiy 20% in infarct volume.
体外研究：
(Arg)9 (Nona-L-arginine; 5-10 μM) provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC50=6 μM).
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